Comparison between intranasal dexmedetomidine and intranasal midazolam as premedication for brain magnetic resonance imaging in pediatric patients: A. Intranasal dexmedetomidine has been used an effective and safe alternative premedication to oral midazolam in children. At a dose of 2micrograms/kg. Background Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable.

Author: Dujora Gashakar
Country: Bosnia & Herzegovina
Language: English (Spanish)
Genre: Automotive
Published (Last): 2 January 2008
Pages: 267
PDF File Size: 17.74 Mb
ePub File Size: 19.25 Mb
ISBN: 900-6-81988-665-8
Downloads: 32221
Price: Free* [*Free Regsitration Required]
Uploader: Shaktizragore

Phan H, Nahata M. Intravenous infusion of dexmedetomidine in gastroscopy. Premedication is required to alleviate anxiety and fear, allow smooth separation from parents, and allow easy acceptance of needle prick for intravenous cannulation and anesthesia induction. Transmucosal administration of midazolam for premedication of pediatric patients. Use in MRI Evidence supports the use of dexmedetomidine for sedation in drxmedetomidine ventilated adult patients.

Minimal change in heart rate and blood pressure were noted.

Hence, a better sedation score was obtained for Group D, similar to the results reported by Sheta et al. Sundaram and Mathian reported similar results.

In this study, we hypothesized dexmedetomiidine IN DEX is effective in providing adequate sedation for non-invasive procedures.

Your email address will not be published.

J Clin Pediatr Dent. This practice is gaining more popularity amongst sedation providers outside of the operating room due to a decrease in emotional stress in children that is related to the IN administration route.


Author information Copyright and License information Disclaimer.

Intranasal Dexmedetomidine as a Sedative for Pediatric Procedural Sedation

Table 1 Demographic data. Use of dexmedetomidine for sedation of children hospitalized in the intensive care unit. Premedication dexmdeetomidine intranasal dexmedetomidine, midazolam and ketamine for children undergoing bone marrow biopsy and aspirate.

However, few studies have reported on the intranasal use of dexmedetomidine in radiological procedures. A comparison of four routes of administration. Group M received intranasal midazolam 0.

In this study, the time of onset of sedation is 8.

Intranasal Dexmedetomidine | Pediatric Sedation Blog

However, midazolam is associated with the risk of respiratory depression and has no analgesic action. This pharmacokinetic profile can facilitate brief periods dexmedetomicine deep sedation often needed for imaging procedures in pediatric sedation.

Except for a longer sleep time, IN DEX was not associated with a higher incidence of adverse events when compared to a cohort that did not receive DEX sedation. Discussion Premedication is required to alleviate anxiety and fear, allow smooth separation from parents, and allow easy acceptance of needle prick for intravenous cannulation and anesthesia induction.

Several studies have reported these unwanted side effects in children. Open in a separate window. Abstract Background and Aims: The success of magnetic resonance imaging MRI as a diagnostic tool has led to its increased use in patients of all age groups; however, children undergoing MRI often require sedation because the magnetic field creates a sound of a very high decibel and to minimize motion artifact.


Preprocedural preparation of children scheduled for magnetic resonance imaging MRI is challenging. Effect of intranasal, rectal and oral routes on plasma midazolam concentrations. On the day of MRI, the nil by mouth status was confirmed, and parental consent was obtained.

Clinical uses of dexmedetomidine in pediatric populations. Preanesthetic assessment included medical and surgical history; general and systemic examination; airway examination; and investigations, such as complete hemogram and renal function tests, conducted on an outpatient basis.

Intranasal Dexmedetomidine

A successful sedation with IN DEX was dexmddetomidine by completion of the non-invasive study without any additional sedative medications required to maintain subject’s sedation. This database was intended to track and study the observed events of sedative medications Table 2 and our current practice.

We compared hemodynamic and respiratory parameters, onset, level, sedation quality, and successful parental separation. A comparative evaluation of intranasal dexmedetomidine, midazolam and ketamin for their sedative and analgesic properties: Please review our privacy policy.

Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients: